
After the unsolved murder of his wife, Adrian Monk develops obsessive-compulsive disorder, which includes his terror of germs and contamination. His condition costs him his job as a prominent homicide detective in the San Francisco Police Department, but he continues to solve crimes with the help of his assistant and his former boss.

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Dr. Kroger retires after his cleaning lady is murdered, so Monk must solve the case to get his therapist back to work.
While at a rock concert looking for Capt. Stottlemeyer's son, Monk investigates a murder.
Monk tries to reconcile with his estranged father (Dan Hedaya).
A millionaire with leprosy comes out of hiding and hires Monk to recover some papers from his estate.