
After discovering that his late father has gone through most of the family fortune, Tod Stiles hits the title trans-America highway in his Corvette in search of adventure with friend Buz Murdock, a survivor of New York's mean streets. The two work odd jobs as they meet and interact with colorful characters and find themselves plunged into one situation after another, some of them romantic, some of them very dangerous. Later, Linc Case, a Vietnam war hero trying to find himself, takes over as Tod's travel companion.
While working at a California veterans' hospital, Tod and Buz attempt to unite a bitter, paraplegic man and the nurse who loves him.
Tod and Buz try to help a confused girl (Julie Newmar) who ran them off the road, when they learn the reasons behind her wild behavior.
A madman threatens to kill a hostage unless the city of Dallas stops "sinning."
A pretty and ambitious executive assistant schemes for a vice-presidency.