
Tom Selleck stars as Frank Reagan, the New York Police Commissioner, and patriarch of the Reagan clan, a multigenerational family of cops. Frank's oldest son is Danny, a seasoned detective and Iraqi War veteran who occasionally uses dubious tactics to solve cases. Daughter Erin, the lone female, is an assistant district attorney. Fresh out of Harvard Law, Jamie is the youngest member and "golden boy" of the family. Jamie gave up a lucrative future in law to continue the family's tradition in police work, and is asked to participate in a secretive investigation that even his father does not know about.

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Erin is designated to lead a federal investigation into corrupt horse racing; Jamie investigates a drug trafficking operation involving rival gangs; Danny and Baez look into a series of assaults in Little Vietnam with the help of a familiar face.
Danny and Baez investigate a homicide involving voodoo with the help of Baez's old partner; Eddie and a fellow officer team up with Capt. McNichols when they suspect a prestigious school is employing discriminatory admission practices.
Jamie works to bust scammers who are defrauding the elderly; Danny and Baez investigate a series of mysterious deaths at a hospital; Anthony wants to take down an attorney who exploits the law for his own financial gain.
Danny and Baez are on edge when Sam Evans, a serial killer who once targeted Baez and her daughter, is released early from prison; Jamie and Anthony team up on an investigation involving one of Anthony's criminal informants.