
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

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House and his team take on the case of a teenage chess prodigy with a mysterious illness and a bad attitude.
The team takes on the case of a woman who was rescued at sea en route from Cuba in her desperate bid to get a diagnosis from Dr. House.
When Cuddy's handyman, Alfredo, falls from her roof and develops strange symptoms, she joins the team to figure out what is wrong with him.
The hospital admits a renowned physician and advocate against the spread of tuberculosis in Africa, and his TB-like symptoms draw media attention which could further his cause.