
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.
House recounts the case of a woman who came to the emergency room with an unexplained illness and no memory of her identity.
The team heads outside the hospital to help provide medical attention at the scene of an emergency.
House and Cuddy explore the ramifications of their feelings for each other; a colleague's illness leaves the hospital without a neurosurgeon on site.
A seemingly healthy 14-year-old collapses during a skateboarding exhibition; House and Cuddy face the challenge of handling their romantic relationship at work.