A women's health clinic in Philadelphia is the setting for this drama. While dealing with a number of medical issues, the show often revolves around the conflict between the clinic's directors: one a passionate advocate for patients and the other a more discipline-oriented doctor.

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Lu uses unconventional methods to treat a patient with a rare and deadly disease.
Lu tries to save a woman's fertility after her appendix ruptures; Kayla tries to amends with her estranged twin sister.
Lu treats a woman who is eight months pregnant; Kayla pretends a patient is still alive to keep his girlfriend calm.
A patient experiences amazing results from an experimental drug; Araya's estranged grandparents visit.