
Emergency room nurse Jackie Peyton does everything she can to provide her patients with the best care possible while navigating the waters of a crumbling health-care system. But she has a secret that is increasingly difficult to keep from people -- she relies on Vicodin and Adderall to get her through high-stress shifts at a New York hospital, where she isn't above bending the rules to keep things running smoothly in the face of indifferent doctors, penny-pinching bean counters and miles of bureaucratic red tape.

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Jackie's fake identity is compromised; Frank moves in; Antoinette badgers Jackie about her sobriety; Prentiss plans a night out with Zoey.
Jackie wants to get sober after Antoinette's startling confession; Jackie finds drugs in Grace's room; Akalitus names Zoey "Nurse of the Month"; Coop's dream comes true.
Jackie goes through detox at home with help from her friends; a dream patient exposes a great fear; Frank objects to Grace's moving back home.
Frank warns Jackie about an upcoming DEA investigation at the hospital; Antoinette turns to Eddie for help; Coop and Carrie look for loopholes; a death causes the staff to reflect.