
Peter Parker is a very intelligent young man. But when Peter gets bitten by a radioactive spider during a school field trip to Oscorp, he develops spider-like powers including the ability to shoot webbing from his hands and to climb up walls. When tragedy strikes close to his home, Peter must decide how to come to terms with the momentous loss but also how he must adjust to his new job as a masked superhero. Peter will face all manner of villains and those looking to cause trouble as he attempts to rid his city of corruption.
Spider-Man teams up with Ms. Marvel to investigate an elite boarding school after its students start displaying out-of-control, super-powered behaviors.
Eddie Brock, who has emerged with the vengeance-filled Venom symbiote, sets his sights on destroying Peter Parker and everything that is Spider-Man.
Spider-Man is two steps behind as Venom kidnaps key figures in Peter Parker's life; demanding a face-off against Peter, Venom holds them hostage at Horizon High.
A mystery villain puts a bounty on Spider-Man's head, bringing on attacks from Panda-Mania, Hippo and Overdrive.