27
8-7
Final: San Francisco 49ers at Indianapolis Colts on Tue Dec 23, 2025
The Colts host the 49ers in clash of playoff contenders. Indianapolis won the last five meetings, last losing to San Francisco 40-21 in 2001. Peyton Manning (IND) was 31-of-51 for 370 yards with a touchdown and four interceptions in that game.
Final: San Francisco 49ers at Indianapolis Colts on Tue Dec 23, 2025
The Colts host the 49ers in clash of playoff contenders. Indianapolis won the last five meetings, last losing to San Francisco 40-21 in 2001. Peyton Manning (IND) was 31-of-51 for 370 yards with a touchdown and four interceptions in that game.
Final: San Francisco 49ers at Indianapolis Colts on Tue Dec 23, 2025
The Colts host the 49ers in clash of playoff contenders. Indianapolis won the last five meetings, last losing to San Francisco 40-21 in 2001. Peyton Manning (IND) was 31-of-51 for 370 yards with a touchdown and four interceptions in that game.
The Colts host the 49ers in clash of playoff contenders. Indianapolis won the last five meetings, last losing to San Francisco 40-21 in 2001. Peyton Manning (IND) was 31-of-51 for 370 yards with a touchdown and four interceptions in that game.
Final
Tue, Dec 23
48
11-4
Standings
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Conference
Overall
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